Macduff’s wife, Lady Macduff, questions Ross about her husband fleeing to England. She doesn’t understand why he would leave his family defenseless at a time like this. Ross tries to reassure her, but no sooner does he leave than a messenger arrives to tell Lady Macduff and her son to run for their lives. But it’s too late—the murderers have arrived, and they kill her son. She flees, the murderers hot on her heels.