DAVINA: “Course” comes from the Latin “currere”, to run, and means a race, a charge, or a bout between two opponents; for example boxers or fencers, who charge at each other. 
RALPH: But another sense comes to mind: the hunting down of a wild animal such as a fox or hare by a pack of hunting dogs. You sense that Macbeth is all alone and being pursued relentlessly on all sides; it’s only a matter of time before he’ll be caught and destroyed.